:root {
  --bg: #f5f7fb;
  --panel: #ffffff;
  --text: #10203f;
  --muted: #60708d;
  --border: #d8e0ef;
  --accent: #2459d6;
  --accent-soft: #eaf1ff;
  --shadow: 0 12px 30px rgba(16, 32, 63, 0.08);
}

* { box-sizing: border-box; }
body {
  margin: 0;
  font-family: Inter, ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
  background: var(--bg);
  color: var(--text);
}
.container { width: min(1180px, calc(100% - 32px)); margin: 0 auto; }
.site-header {
  background: linear-gradient(135deg, #10203f, #2459d6);
  color: white;
  padding: 42px 0 34px;
}
.eyebrow { margin: 0 0 8px; text-transform: uppercase; letter-spacing: .12em; font-size: 12px; opacity: .78; font-weight: 700; }
h1 { margin: 0; font-size: clamp(28px, 4vw, 44px); line-height: 1.05; }
.lede { max-width: 820px; font-size: 18px; opacity: .9; }
.disclaimer { max-width: 900px; font-size: 13px; opacity: .75; }
.controls, .table-wrap, .summary {
  background: var(--panel);
  border: 1px solid var(--border);
  box-shadow: var(--shadow);
  border-radius: 20px;
}
.controls { padding: 20px; margin-top: -22px; position: relative; }
.search-row { display: grid; gap: 8px; margin-bottom: 16px; }
label { font-weight: 700; font-size: 13px; color: var(--text); }
input, select, button {
  font: inherit;
  border-radius: 12px;
  border: 1px solid var(--border);
}
input, select { width: 100%; padding: 11px 12px; background: white; color: var(--text); }
input:focus, select:focus { outline: 3px solid var(--accent-soft); border-color: var(--accent); }
.filter-grid { display: grid; grid-template-columns: repeat(4, 1fr); gap: 14px; }
.button-row { display: flex; gap: 10px; margin-top: 16px; flex-wrap: wrap; }
button { padding: 10px 14px; background: var(--accent); color: white; border-color: var(--accent); cursor: pointer; font-weight: 700; }
button:hover { filter: brightness(0.95); }
button#downloadButton { background: white; color: var(--accent); }
.summary { margin: 18px 0; padding: 14px 18px; display: flex; justify-content: space-between; gap: 14px; color: var(--muted); }
.summary strong { color: var(--text); font-size: 20px; }
.table-wrap { overflow-x: auto; margin-bottom: 40px; }
.results-table { width: 100%; border-collapse: collapse; min-width: 900px; }
th { position: sticky; top: 0; background: #f8faff; z-index: 1; text-align: left; font-size: 13px; letter-spacing: .01em; color: var(--muted); border-bottom: 1px solid var(--border); padding: 12px; }
td { border-bottom: 1px solid var(--border); padding: 12px; vertical-align: top; }
.result-row:hover { background: #fbfdff; }
.expand-col { width: 44px; text-align: center; }
.expand-btn { width: 28px; height: 28px; padding: 0; border-radius: 999px; background: white; color: var(--accent); border-color: var(--border); }
.drug-cell { min-width: 230px; font-weight: 650; }
.chips { display: flex; flex-wrap: wrap; gap: 6px; }
.chip { display: inline-flex; align-items: center; padding: 4px 8px; border-radius: 999px; background: var(--accent-soft); color: #071b4d; font-size: 13px; font-weight: 650; }
mark { background: #fff29b; padding: 0 2px; border-radius: 3px; }
.details-row td { background: #fbfcff; border-bottom: 1px solid var(--border); }
.detail-grid { display: grid; grid-template-columns: repeat(4, 1fr); gap: 12px; }
.detail-grid div { background: white; border: 1px solid var(--border); border-radius: 14px; padding: 12px; }
.detail-grid strong { display: block; font-size: 12px; color: var(--muted); margin-bottom: 5px; }
.detail-grid span { font-size: 14px; }
.raw-details { margin-top: 12px; }
.raw-details summary { color: var(--muted); cursor: pointer; font-weight: 700; }
pre { white-space: pre-wrap; background: #f4f7fc; border: 1px solid var(--border); border-radius: 12px; padding: 12px; max-height: 280px; overflow: auto; font-size: 12px; }
.empty { padding: 30px; color: var(--muted); text-align: center; }
.beta-badge { display: inline-block; font-size: 14px; font-weight: 700; letter-spacing: .06em; text-transform: uppercase; background: rgba(255,255,255,.18); color: white; border: 1px solid rgba(255,255,255,.4); border-radius: 6px; padding: 3px 9px; vertical-align: middle; margin-left: 10px; line-height: 1.5; }
.site-footer { background: var(--text); color: rgba(255,255,255,.7); font-size: 13px; padding: 28px 0; margin-top: 20px; }
.site-footer p { margin: 0 0 6px; }
.site-footer p:last-child { margin-bottom: 0; }
.site-footer a { color: rgba(255,255,255,.85); text-underline-offset: 3px; }
.site-footer a:hover { color: white; }
@media (max-width: 850px) {
  .filter-grid { grid-template-columns: 1fr 1fr; }
  .detail-grid { grid-template-columns: 1fr 1fr; }
  .summary { flex-direction: column; }
}
@media (max-width: 560px) {
  .filter-grid, .detail-grid { grid-template-columns: 1fr; }
  .container { width: min(100% - 20px, 1180px); }
}